SPKB

Signal Peptide Knowledge Base

General Information


SPKB ID  SPKB02543

Signal sequence   MDYLLMIFSLLFVACQG

Length  17

Organism  Homo sapiens (Human)

UniProt ID  P05305,

Motif  1..17



Activity Information


Pathway  SRP-dependent

Natural/Artificial  Natural

Subcellular location  ER

Secretion efficiency  NA

Type  Sec/SPI



Structure Information


PDB ID  NA,

Predicted Structure ID  SPKB02543.cif

Structure  SPKB02543.cif
Very high (pLDDT > 90)
Confident (90 > pLDDT > 70)
Low (70 > pLDDT > 50)
Very low (pLDDT < 50)
Loading PAE…
Expected Position Error (Ångströms)


Physicochemical Information


Molecular weight  1964.42624

Aliphatic index  137.6470588

Isoelectric point  3.749971056

Charge (pH=7)   -1.064394347

Topological polar surface area  649.77

Aromaticity  0.176470588

Average rotatable bonds  3.705882353

Number of hydrogen bond donors  23

Number of hydrogen bond acceptors  25

X logP energy  -0.7049

Hydropathy 



Literature Information


Title  The signal peptide of human preproendothelin-1.

DOI  10.1016/0014-5793(91)80948-3,

Publication Year  1991

PubMed ID  1864385,

Patent ID  NA,



Faculty of Applied Sciences, Macao Polytechnic University, Macao, China.