SPKB

Signal Peptide Knowledge Base

General Information


SPKB ID  SPKB02541

Signal sequence   MLGPCMLLLLLLLGLRLQLSLG

Length  22

Organism  Homo sapiens (Human)

UniProt ID  P05187,

Motif  1..22



Activity Information


Pathway  SRP-dependent

Natural/Artificial  Natural

Subcellular location  ER

Secretion efficiency  NA

Type  Sec/SPI



Structure Information


PDB ID  NA,

Predicted Structure ID  SPKB02541.cif

Structure  SPKB02541.cif
Very high (pLDDT > 90)
Confident (90 > pLDDT > 70)
Low (70 > pLDDT > 50)
Very low (pLDDT < 50)
Loading PAE…
Expected Position Error (Ångströms)


Physicochemical Information


Molecular weight  2381.12084

Aliphatic index  212.7272727

Isoelectric point  8.549912035

Charge (pH=7)   0.936006272

Topological polar surface area  790.85

Aromaticity  0

Average rotatable bonds  3.681818182

Number of hydrogen bond donors  28

Number of hydrogen bond acceptors  29

X logP energy  -0.51023

Hydropathy 



Literature Information


Title  Purification and partial sequencing of human placental alkaline phosphatase.

DOI  10.1016/s0006-291x(83)80252-6,

Publication Year  1983

PubMed ID  6651840,

Patent ID  NA,



Faculty of Applied Sciences, Macao Polytechnic University, Macao, China.