SPKB

Signal Peptide Knowledge Base

General Information


SPKB ID  SPKB02533

Signal sequence   MVMLLLLLSALAGLFGAAEG

Length  20

Organism  Homo sapiens (Human)

UniProt ID  P05090,

Motif  1..20



Activity Information


Pathway  SRP-dependent

Natural/Artificial  Natural

Subcellular location  ER

Secretion efficiency  NA

Type  Sec/SPI



Structure Information


PDB ID  NA,

Predicted Structure ID  SPKB02533.cif

Structure  SPKB02533.cif
Very high (pLDDT > 90)
Confident (90 > pLDDT > 70)
Low (70 > pLDDT > 50)
Very low (pLDDT < 50)
Loading PAE…
Expected Position Error (Ångströms)


Physicochemical Information


Molecular weight  1990.49004

Aliphatic index  171

Isoelectric point  3.849983241

Charge (pH=7)   -1.000240578

Topological polar surface area  673.75

Aromaticity  0.05

Average rotatable bonds  3.3

Number of hydrogen bond donors  23

Number of hydrogen bond acceptors  25

X logP energy  -1.832

Hydropathy 



Literature Information


Title  Structure of human apolipoprotein D: locations of the intermolecular and intramolecular disulfide links.

DOI  10.1021/bi00207a011,

Publication Year  1994

PubMed ID  7918467,

Patent ID  NA,



Faculty of Applied Sciences, Macao Polytechnic University, Macao, China.