SPKB

Signal Peptide Knowledge Base

General Information


SPKB ID  SPKB02531

Signal sequence   MQPTLLLSLLGAVGLAAVNS

Length  20

Organism  Homo sapiens (Human)

UniProt ID  P05060,

Motif  1..20



Activity Information


Pathway  SRP-dependent

Natural/Artificial  Natural

Subcellular location  ER

Secretion efficiency  NA

Type  Sec/SPI



Structure Information


PDB ID  NA,

Predicted Structure ID  SPKB02531.cif

Structure  SPKB02531.cif
Very high (pLDDT > 90)
Confident (90 > pLDDT > 70)
Low (70 > pLDDT > 50)
Very low (pLDDT < 50)
Loading PAE…
Expected Position Error (Ångströms)


Physicochemical Information


Molecular weight  1968.38234

Aliphatic index  161

Isoelectric point  6.099999998

Charge (pH=7)   -0.002015701

Topological polar surface area  754.3

Aromaticity  0

Average rotatable bonds  3.15

Number of hydrogen bond donors  25

Number of hydrogen bond acceptors  27

X logP energy  -6.7138

Hydropathy 



Literature Information


Title  Chromogranin B: isolation from pheochromocytoma, N-terminal sequence, tissue distribution and secretory vesicle processing.

DOI  10.1016/0167-0115(91)90216-4,

Publication Year  1991

PubMed ID  1882087,

Patent ID  NA,



Faculty of Applied Sciences, Macao Polytechnic University, Macao, China.