SPKB

Signal Peptide Knowledge Base

General Information


SPKB ID  SPKB02530

Signal sequence   MRSAAVLALLLCAGQVIA

Length  18

Organism  Bos taurus (Bovine)

UniProt ID  P05059,

Motif  1..18



Activity Information


Pathway  SRP-dependent

Natural/Artificial  Natural

Subcellular location  ER

Secretion efficiency  NA

Type  Sec/SPI



Structure Information


PDB ID  NA,

Predicted Structure ID  SPKB02530.cif

Structure  SPKB02530.cif
Very high (pLDDT > 90)
Confident (90 > pLDDT > 70)
Low (70 > pLDDT > 50)
Very low (pLDDT < 50)
Loading PAE…
Expected Position Error (Ångströms)


Physicochemical Information


Molecular weight  1800.25114

Aliphatic index  168.3333333

Isoelectric point  8.549912035

Charge (pH=7)   0.936006272

Topological polar surface area  683.24

Aromaticity  0

Average rotatable bonds  3.277777778

Number of hydrogen bond donors  25

Number of hydrogen bond acceptors  24

X logP energy  -4.88273

Hydropathy 



Literature Information


Title  Primary sequence characterization of catestatin intermediates and peptides defines proteolytic cleavage sites utilized for converting chromogranin a into active catestatin secreted from neuroendocrine chromaffin cells.

DOI  10.1021/bi0300433,

Publication Year  2003

PubMed ID  12795588,

Patent ID  NA,



Faculty of Applied Sciences, Macao Polytechnic University, Macao, China.