SPKB

Signal Peptide Knowledge Base

General Information


SPKB ID  SPKB02527

Signal sequence   MANLGYWLLALFVTMWTDVGLC

Length  22

Organism  Mus musculus (Mouse)

UniProt ID  P04925,

Motif  1..22



Activity Information


Pathway  SRP-dependent

Natural/Artificial  Natural

Subcellular location  ER

Secretion efficiency  NA

Type  Sec/SPI



Structure Information


PDB ID  7TD6,

Predicted Structure ID  SPKB02527.cif

Structure  SPKB02527.cif
Very high (pLDDT > 90)
Confident (90 > pLDDT > 70)
Low (70 > pLDDT > 50)
Very low (pLDDT < 50)
Loading PAE…
Expected Position Error (Ångströms)


Physicochemical Information


Molecular weight  2518.04444

Aliphatic index  124.0909091

Isoelectric point  3.749971056

Charge (pH=7)   -1.064394347

Topological polar surface area  847.08

Aromaticity  0.181818182

Average rotatable bonds  3.454545455

Number of hydrogen bond donors  31

Number of hydrogen bond acceptors  31

X logP energy  -1.3891

Hydropathy 



Literature Information


Title  Molecular pathology of scrapie-associated fibril protein (PrP) in mouse brain affected by the ME7 strain of scrapie.

DOI  10.1111/j.1432-1033.1988.tb13883.x,

Publication Year  1988

PubMed ID  2894984,

Patent ID  NA,



Faculty of Applied Sciences, Macao Polytechnic University, Macao, China.