SPKB

Signal Peptide Knowledge Base

General Information


SPKB ID  SPKB02519

Signal sequence   MAVMAPRTLLLLLSGALALTQTWA

Length  24

Organism  Homo sapiens (Human)

UniProt ID  P04439,

Motif  1..24



Activity Information


Pathway  SRP-dependent

Natural/Artificial  Natural

Subcellular location  ER

Secretion efficiency  NA

Type  Sec/SPI



Structure Information


PDB ID  8RBU,

Predicted Structure ID  SPKB02519.cif

Structure  SPKB02519.cif
Very high (pLDDT > 90)
Confident (90 > pLDDT > 70)
Low (70 > pLDDT > 50)
Very low (pLDDT < 50)
Loading PAE…
Expected Position Error (Ångströms)


Physicochemical Information


Molecular weight  2542.13634

Aliphatic index  146.6666667

Isoelectric point  10.55000222

Charge (pH=7)   0.997980988

Topological polar surface area  925.53

Aromaticity  0.041666667

Average rotatable bonds  3.333333333

Number of hydrogen bond donors  33

Number of hydrogen bond acceptors  33

X logP energy  -5.34183

Hydropathy 



Literature Information


Title  Comparison of amino acid sequences of two human histocompatibility antigens, HLA-A2 and HLA-B7: location of putative alloantigenic sites.

DOI  10.1073/pnas.76.9.4395,

Publication Year  1979

PubMed ID  92029,

Patent ID  NA,



Faculty of Applied Sciences, Macao Polytechnic University, Macao, China.