SPKB

Signal Peptide Knowledge Base

General Information


SPKB ID  SPKB02501

Signal sequence   MHPPKTPSGALHRKRKMAAWPFSRLWKVSDPILFQMTLIAALLPAVLG

Length  48

Organism  Homo sapiens (Human)

UniProt ID  P04003,

Motif  1..48



Activity Information


Pathway  SRP-dependent

Natural/Artificial  Natural

Subcellular location  ER

Secretion efficiency  NA

Type  Sec/SPI



Structure Information


PDB ID  NA,

Predicted Structure ID  SPKB02501.cif

Structure  SPKB02501.cif
Very high (pLDDT > 90)
Confident (90 > pLDDT > 70)
Low (70 > pLDDT > 50)
Very low (pLDDT < 50)
Loading PAE…
Expected Position Error (Ångströms)


Physicochemical Information


Molecular weight  5380.55444

Aliphatic index  97.70833333

Isoelectric point  12.28022265

Charge (pH=7)   6.179058896

Topological polar surface area  1938.54

Aromaticity  0.083333333

Average rotatable bonds  3.5

Number of hydrogen bond donors  67

Number of hydrogen bond acceptors  68

X logP energy  -10.76099

Hydropathy 



Literature Information


Title  Amino acid sequence studies of human C4b-binding protein: N-terminal sequence analysis and alignment of the fragments produced by limited proteolysis with chymotrypsin and the peptides produced by cyanogen bromide treatment.

DOI  10.1016/0161-5890(85)90127-0,

Publication Year  1985

PubMed ID  4033666,

Patent ID  NA,



Faculty of Applied Sciences, Macao Polytechnic University, Macao, China.