SPKB

Signal Peptide Knowledge Base

General Information


SPKB ID  SPKB02499

Signal sequence   MKSSGLFPFLVLLALGTLAPWAVEG

Length  25

Organism  Homo sapiens (Human)

UniProt ID  P03973,

Motif  1..25



Activity Information


Pathway  SRP-dependent

Natural/Artificial  Natural

Subcellular location  ER

Secretion efficiency  NA

Type  Sec/SPI



Structure Information


PDB ID  NA,

Predicted Structure ID  SPKB02499.cif

Structure  SPKB02499.cif
Very high (pLDDT > 90)
Confident (90 > pLDDT > 70)
Low (70 > pLDDT > 50)
Very low (pLDDT < 50)
Loading PAE…
Expected Position Error (Ångströms)


Physicochemical Information


Molecular weight  2618.17244

Aliphatic index  128.8

Isoelectric point  6.408795646

Charge (pH=7)   -0.000535612

Topological polar surface area  883.94

Aromaticity  0.12

Average rotatable bonds  3.2

Number of hydrogen bond donors  30

Number of hydrogen bond acceptors  32

X logP energy  -3.0899

Hydropathy 



Literature Information


Title  Purification and characterization of elastase-specific inhibitor. Sequence homology with mucus proteinase inhibitor.

DOI  10.1515/bchm3.1991.372.1.13,

Publication Year  1991

PubMed ID  2039600,

Patent ID  NA,



Faculty of Applied Sciences, Macao Polytechnic University, Macao, China.