SPKB

Signal Peptide Knowledge Base

General Information


SPKB ID  SPKB02490

Signal sequence   MKKLLPILIGLSLSGFSSLSQA

Length  22

Organism  Escherichia coli (strain K12)

UniProt ID  P02930,

Motif  1..22



Activity Information


Pathway  Sec

Natural/Artificial  Natural

Subcellular location  Cell membrane

Secretion efficiency  NA

Type  Sec/SPI



Structure Information


PDB ID  5NG5,

Predicted Structure ID  SPKB02490.cif

Structure  SPKB02490.cif
Very high (pLDDT > 90)
Confident (90 > pLDDT > 70)
Low (70 > pLDDT > 50)
Very low (pLDDT < 50)
Loading PAE…
Expected Position Error (Ångströms)


Physicochemical Information


Molecular weight  2303.82884

Aliphatic index  146.3636364

Isoelectric point  10.80537956

Charge (pH=7)   1.997394232

Topological polar surface area  861.91

Aromaticity  0.045454545

Average rotatable bonds  3.590909091

Number of hydrogen bond donors  30

Number of hydrogen bond acceptors  32

X logP energy  -6.7824

Hydropathy 



Literature Information


Title  Identification and characterization of the TolC protein, an outer membrane protein from Escherichia coli.

DOI  10.1128/jb.153.2.693-699.1983,

Publication Year  1983

PubMed ID  6337123,

Patent ID  NA,



Faculty of Applied Sciences, Macao Polytechnic University, Macao, China.