SPKB

Signal Peptide Knowledge Base

General Information


SPKB ID  SPKB02479

Signal sequence   MKLVFLVLLFLGALGLCLA

Length  19

Organism  Homo sapiens (Human)

UniProt ID  P02788,

Motif  1..19



Activity Information


Pathway  SRP-dependent

Natural/Artificial  Natural

Subcellular location  ER

Secretion efficiency  NA

Type  Sec/SPI



Structure Information


PDB ID  NA,

Predicted Structure ID  SPKB02479.cif

Structure  SPKB02479.cif
Very high (pLDDT > 90)
Confident (90 > pLDDT > 70)
Low (70 > pLDDT > 50)
Very low (pLDDT < 50)
Loading PAE…
Expected Position Error (Ångströms)


Physicochemical Information


Molecular weight  2034.67574

Aliphatic index  205.2631579

Isoelectric point  8.545189979

Charge (pH=7)   0.93571455

Topological polar surface area  613.14

Aromaticity  0.105263158

Average rotatable bonds  3.526315789

Number of hydrogen bond donors  22

Number of hydrogen bond acceptors  23

X logP energy  2.4054

Hydropathy 



Literature Information


Title  One of two human lactoferrin variants exhibits increased antibacterial and transcriptional activation activities and is associated with localized juvenile periodontitis.

DOI  10.1128/IAI.71.11.6141-6147.2003,

Publication Year  2003

PubMed ID  14573629,

Patent ID  NA,



Faculty of Applied Sciences, Macao Polytechnic University, Macao, China.