SPKB

Signal Peptide Knowledge Base

General Information


SPKB ID  SPKB02471

Signal sequence   MKWVESIFLIFLLNFTES

Length  18

Organism  Homo sapiens (Human)

UniProt ID  P02771,

Motif  1..18



Activity Information


Pathway  SRP-dependent

Natural/Artificial  Natural

Subcellular location  ER

Secretion efficiency  NA

Type  Sec/SPI



Structure Information


PDB ID  7YIM,

Predicted Structure ID  SPKB02471.cif

Structure  SPKB02471.cif
Very high (pLDDT > 90)
Confident (90 > pLDDT > 70)
Low (70 > pLDDT > 50)
Very low (pLDDT < 50)
Loading PAE…
Expected Position Error (Ångströms)


Physicochemical Information


Molecular weight  2217.65084

Aliphatic index  124.4444444

Isoelectric point  4.258147297

Charge (pH=7)   -0.998760489

Topological polar surface area  778.21

Aromaticity  0.222222222

Average rotatable bonds  4

Number of hydrogen bond donors  27

Number of hydrogen bond acceptors  27

X logP energy  -1.169

Hydropathy 



Literature Information


Title  Human alpha-fetoprotein primary structure: a mass spectrometric study.

DOI  10.1021/bi00234a032,

Publication Year  1991

PubMed ID  1709810,

Patent ID  NA,



Faculty of Applied Sciences, Macao Polytechnic University, Macao, China.