SPKB

Signal Peptide Knowledge Base

General Information


SPKB ID  SPKB02465

Signal sequence   MALSWVLTVLSLLPLLEA

Length  18

Organism  Homo sapiens (Human)

UniProt ID  P02763,

Motif  1..18



Activity Information


Pathway  SRP-dependent

Natural/Artificial  Natural

Subcellular location  ER

Secretion efficiency  NA

Type  Sec/SPI



Structure Information


PDB ID  NA,

Predicted Structure ID  SPKB02465.cif

Structure  SPKB02465.cif
Very high (pLDDT > 90)
Confident (90 > pLDDT > 70)
Low (70 > pLDDT > 50)
Very low (pLDDT < 50)
Loading PAE…
Expected Position Error (Ångströms)


Physicochemical Information


Molecular weight  1969.45334

Aliphatic index  195

Isoelectric point  3.849983241

Charge (pH=7)   -1.000240578

Topological polar surface area  663.01

Aromaticity  0.055555556

Average rotatable bonds  3.388888889

Number of hydrogen bond donors  23

Number of hydrogen bond acceptors  24

X logP energy  -0.4721

Hydropathy 



Literature Information


Title  Structure of 1 -acid glycoprotein. The complete amino acid sequence, multiple amino acid substitutions, and homology with the immunoglobulins.

DOI  10.1021/bi00738a026,

Publication Year  1973

PubMed ID  4711474,

Patent ID  NA,



Faculty of Applied Sciences, Macao Polytechnic University, Macao, China.