SPKB

Signal Peptide Knowledge Base

General Information


SPKB ID  SPKB02456

Signal sequence   MSACRSFAVAICILEISILTA

Length  21

Organism  Homo sapiens (Human)

UniProt ID  P02748,

Motif  1..21



Activity Information


Pathway  SRP-dependent

Natural/Artificial  Natural

Subcellular location  ER

Secretion efficiency  NA

Type  Sec/SPI



Structure Information


PDB ID  8B0G,

Predicted Structure ID  SPKB02456.cif

Structure  SPKB02456.cif
Very high (pLDDT > 90)
Confident (90 > pLDDT > 70)
Low (70 > pLDDT > 50)
Very low (pLDDT < 50)
Loading PAE…
Expected Position Error (Ångströms)


Physicochemical Information


Molecular weight  2212.70894

Aliphatic index  144.2857143

Isoelectric point  6.135737489

Charge (pH=7)   -0.124193321

Topological polar surface area  825.44

Aromaticity  0.047619048

Average rotatable bonds  3.428571429

Number of hydrogen bond donors  32

Number of hydrogen bond acceptors  31

X logP energy  -6.55233

Hydropathy 



Literature Information


Title  Nucleotide sequence of cDNA and derived amino acid sequence of human complement component C9.

DOI  10.1073/pnas.81.23.7298,

Publication Year  1984

PubMed ID  6095282,

Patent ID  NA,



Faculty of Applied Sciences, Macao Polytechnic University, Macao, China.