SPKB

Signal Peptide Knowledge Base

General Information


SPKB ID  SPKB02454

Signal sequence   MMMKIPWGSIPVLMLLLLLGLIDISQA

Length  27

Organism  Homo sapiens (Human)

UniProt ID  P02746,

Motif  1..27



Activity Information


Pathway  SRP-dependent

Natural/Artificial  Natural

Subcellular location  ER

Secretion efficiency  NA

Type  Sec/SPI



Structure Information


PDB ID  NA,

Predicted Structure ID  SPKB02454.cif

Structure  SPKB02454.cif
Very high (pLDDT > 90)
Confident (90 > pLDDT > 70)
Low (70 > pLDDT > 50)
Very low (pLDDT < 50)
Loading PAE…
Expected Position Error (Ångströms)


Physicochemical Information


Molecular weight  2997.85064

Aliphatic index  173.3333333

Isoelectric point  6.337367167

Charge (pH=7)   -0.00186425

Topological polar surface area  965

Aromaticity  0.037037037

Average rotatable bonds  3.666666667

Number of hydrogen bond donors  32

Number of hydrogen bond acceptors  37

X logP energy  0.0515

Hydropathy 



Literature Information


Title  Complete amino acid sequences of the three collagen-like regions present in subcomponent C1q of the first component of human complement.

DOI  10.1042/bj1790367,

Publication Year  1979

PubMed ID  486087,

Patent ID  NA,



Faculty of Applied Sciences, Macao Polytechnic University, Macao, China.