SPKB

Signal Peptide Knowledge Base

General Information


SPKB ID  SPKB02452

Signal sequence   MNKPLLWISVLTSLLEAFA

Length  19

Organism  Homo sapiens (Human)

UniProt ID  P02743,

Motif  1..19



Activity Information


Pathway  SRP-dependent

Natural/Artificial  Natural

Subcellular location  ER

Secretion efficiency  NA

Type  Sec/SPI



Structure Information


PDB ID  NA,

Predicted Structure ID  SPKB02452.cif

Structure  SPKB02452.cif
Very high (pLDDT > 90)
Confident (90 > pLDDT > 70)
Low (70 > pLDDT > 50)
Very low (pLDDT < 50)
Loading PAE…
Expected Position Error (Ångströms)


Physicochemical Information


Molecular weight  2146.61584

Aliphatic index  148.9473684

Isoelectric point  6.408795646

Charge (pH=7)   -0.000535612

Topological polar surface area  761.22

Aromaticity  0.105263158

Average rotatable bonds  3.578947368

Number of hydrogen bond donors  26

Number of hydrogen bond acceptors  27

X logP energy  -2.4423

Hydropathy 



Literature Information


Title  The primary structure of human tissue amyloid P component from a patient with primary idiopathic amyloidosis.

DOI  NA,

Publication Year  1985

PubMed ID  4055725,

Patent ID  NA,



Faculty of Applied Sciences, Macao Polytechnic University, Macao, China.