SPKB

Signal Peptide Knowledge Base

General Information


SPKB ID  SPKB02431

Signal sequence   MRLFLSLPVLVVVLSIVLEGPAPAQG

Length  26

Organism  Homo sapiens (Human)

UniProt ID  P02654,

Motif  1..26



Activity Information


Pathway  SRP-dependent

Natural/Artificial  Natural

Subcellular location  ER

Secretion efficiency  NA

Type  Sec/SPI



Structure Information


PDB ID  6DVU,

Predicted Structure ID  SPKB02431.cif

Structure  SPKB02431.cif
Very high (pLDDT > 90)
Confident (90 > pLDDT > 70)
Low (70 > pLDDT > 50)
Very low (pLDDT < 50)
Loading PAE…
Expected Position Error (Ångströms)


Physicochemical Information


Molecular weight  2719.36484

Aliphatic index  168.4615385

Isoelectric point  6.410149741

Charge (pH=7)   -0.000243889

Topological polar surface area  947.2

Aromaticity  0.038461538

Average rotatable bonds  3.230769231

Number of hydrogen bond donors  31

Number of hydrogen bond acceptors  33

X logP energy  -3.68383

Hydropathy 



Literature Information


Title  Thf complete amino acid sequence of C-I (apoLp-Ser), an apolipoprotein from human very low density lipoproteins.

DOI  NA,

Publication Year  1975

PubMed ID  166984,

Patent ID  NA,



Faculty of Applied Sciences, Macao Polytechnic University, Macao, China.