SPKB

Signal Peptide Knowledge Base

General Information


SPKB ID  SPKB02429

Signal sequence   MKVLWAALLVTFLAGCQA

Length  18

Organism  Homo sapiens (Human)

UniProt ID  P02649,

Motif  1..18



Activity Information


Pathway  SRP-dependent

Natural/Artificial  Natural

Subcellular location  ER

Secretion efficiency  NA

Type  Sec/SPI



Structure Information


PDB ID  6V7M,

Predicted Structure ID  SPKB02429.cif

Structure  SPKB02429.cif
Very high (pLDDT > 90)
Confident (90 > pLDDT > 70)
Low (70 > pLDDT > 50)
Very low (pLDDT < 50)
Loading PAE…
Expected Position Error (Ångströms)


Physicochemical Information


Molecular weight  1935.41624

Aliphatic index  141.1111111

Isoelectric point  8.545189979

Charge (pH=7)   0.93571455

Topological polar surface area  663.15

Aromaticity  0.111111111

Average rotatable bonds  3.388888889

Number of hydrogen bond donors  24

Number of hydrogen bond acceptors  24

X logP energy  -1.7278

Hydropathy 



Literature Information


Title  Human apolipoprotein E. The complete amino acid sequence.

DOI  NA,

Publication Year  1982

PubMed ID  7068630,

Patent ID  NA,



Faculty of Applied Sciences, Macao Polytechnic University, Macao, China.