SPKB

Signal Peptide Knowledge Base

General Information


SPKB ID  SPKB02427

Signal sequence   MKAAVLTLAVLFLTGSQA

Length  18

Organism  Homo sapiens (Human)

UniProt ID  P02647,

Motif  1..18



Activity Information


Pathway  SRP-dependent

Natural/Artificial  Natural

Subcellular location  ER

Secretion efficiency  NA

Type  Sec/SPI



Structure Information


PDB ID  NA,

Predicted Structure ID  SPKB02427.cif

Structure  SPKB02427.cif
Very high (pLDDT > 90)
Confident (90 > pLDDT > 70)
Low (70 > pLDDT > 50)
Very low (pLDDT < 50)
Loading PAE…
Expected Position Error (Ångströms)


Physicochemical Information


Molecular weight  1834.24754

Aliphatic index  141.1111111

Isoelectric point  9.700002532

Charge (pH=7)   0.997689266

Topological polar surface area  687.82

Aromaticity  0.055555556

Average rotatable bonds  3.333333333

Number of hydrogen bond donors  24

Number of hydrogen bond acceptors  25

X logP energy  -5.0085

Hydropathy 



Literature Information


Title  Human apolipoproteins AI, AII, CII and CIII. cDNA sequences and mRNA abundance.

DOI  10.1093/nar/12.9.3917,

Publication Year  1984

PubMed ID  6328445,

Patent ID  NA,



Faculty of Applied Sciences, Macao Polytechnic University, Macao, China.