SPKB

Signal Peptide Knowledge Base

General Information


SPKB ID  SPKB02425

Signal sequence   MGPRLSVWLLLLPAALLLHEEHSRAAA

Length  27

Organism  Homo sapiens (Human)

UniProt ID  P02462,

Motif  1..27



Activity Information


Pathway  SRP-dependent

Natural/Artificial  Natural

Subcellular location  ER

Secretion efficiency  NA

Type  Sec/SPI



Structure Information


PDB ID  NA,

Predicted Structure ID  SPKB02425.cif

Structure  SPKB02425.cif
Very high (pLDDT > 90)
Confident (90 > pLDDT > 70)
Low (70 > pLDDT > 50)
Very low (pLDDT < 50)
Loading PAE…
Expected Position Error (Ångströms)


Physicochemical Information


Molecular weight  2965.55274

Aliphatic index  144.8148148

Isoelectric point  7.715289385

Charge (pH=7)   0.183346104

Topological polar surface area  1114.35

Aromaticity  0.037037037

Average rotatable bonds  3.444444444

Number of hydrogen bond donors  39

Number of hydrogen bond acceptors  37

X logP energy  -5.57936

Hydropathy 



Literature Information


Title  Amino acid sequence of the N-terminal aggregation and cross-linking region (7S domain) of the alpha 1 (IV) chain of human basement membrane collagen.

DOI  10.1111/j.1432-1033.1985.tb09186.x,

Publication Year  1985

PubMed ID  4043082,

Patent ID  NA,



Faculty of Applied Sciences, Macao Polytechnic University, Macao, China.