SPKB

Signal Peptide Knowledge Base

General Information


SPKB ID  SPKB02423

Signal sequence   MVCLKLPGGSCMTALTVTLMVLSSPLALS

Length  29

Organism  Homo sapiens (Human)

UniProt ID  P01911,

Motif  1..29



Activity Information


Pathway  SRP-dependent

Natural/Artificial  Natural

Subcellular location  ER

Secretion efficiency  NA

Type  Sec/SPI



Structure Information


PDB ID  8VRW,

Predicted Structure ID  SPKB02423.cif

Structure  SPKB02423.cif
Very high (pLDDT > 90)
Confident (90 > pLDDT > 70)
Low (70 > pLDDT > 50)
Very low (pLDDT < 50)
Loading PAE…
Expected Position Error (Ångströms)


Physicochemical Information


Molecular weight  2937.68124

Aliphatic index  131.0344828

Isoelectric point  8.229691165

Charge (pH=7)   0.873739834

Topological polar surface area  1028.17

Aromaticity  0

Average rotatable bonds  3.24137931

Number of hydrogen bond donors  38

Number of hydrogen bond acceptors  43

X logP energy  -9.0621

Hydropathy 



Literature Information


Title  N-terminal amino acid sequences of the alpha and beta chains of HLA-DR1 and HLA-DR2 antigens.

DOI  10.1021/bi00270a027,

Publication Year  1983

PubMed ID  6600932,

Patent ID  NA,



Faculty of Applied Sciences, Macao Polytechnic University, Macao, China.