SPKB

Signal Peptide Knowledge Base

General Information


SPKB ID  SPKB02409

Signal sequence   MDILCSTLLLLTVPSWVLS

Length  19

Organism  Homo sapiens (Human)

UniProt ID  P01814,

Motif  1..19



Activity Information


Pathway  SRP-dependent

Natural/Artificial  Natural

Subcellular location  ER

Secretion efficiency  NA

Type  Sec/SPI



Structure Information


PDB ID  7MU4,

Predicted Structure ID  SPKB02409.cif

Structure  SPKB02409.cif
Very high (pLDDT > 90)
Confident (90 > pLDDT > 70)
Low (70 > pLDDT > 50)
Very low (pLDDT < 50)
Loading PAE…
Expected Position Error (Ångströms)


Physicochemical Information


Molecular weight  2104.59094

Aliphatic index  174.2105263

Isoelectric point  3.749971454

Charge (pH=7)   -1.063543932

Topological polar surface area  732.57

Aromaticity  0.052631579

Average rotatable bonds  3.421052632

Number of hydrogen bond donors  27

Number of hydrogen bond acceptors  28

X logP energy  -3.1143

Hydropathy 



Literature Information


Title  Complete amino acid sequence of the Mu heavy chain of a human IgM immunoglobulin.

DOI  10.1126/science.182.4109.287,

Publication Year  1973

PubMed ID  4742735,

Patent ID  NA,



Faculty of Applied Sciences, Macao Polytechnic University, Macao, China.