SPKB

Signal Peptide Knowledge Base

General Information


SPKB ID  SPKB02404

Signal sequence   MNRGVPFRHLLLVLQLALLPAATQG

Length  25

Organism  Homo sapiens (Human)

UniProt ID  P01730,

Motif  1..25



Activity Information


Pathway  SRP-dependent

Natural/Artificial  Natural

Subcellular location  ER

Secretion efficiency  NA

Type  Sec/SPI



Structure Information


PDB ID  4Q6I,

Predicted Structure ID  SPKB02404.cif

Structure  SPKB02404.cif
Very high (pLDDT > 90)
Confident (90 > pLDDT > 70)
Low (70 > pLDDT > 50)
Very low (pLDDT < 50)
Loading PAE…
Expected Position Error (Ångströms)


Physicochemical Information


Molecular weight  2729.32544

Aliphatic index  144.4

Isoelectric point  12.50011018

Charge (pH=7)   2.088886768

Topological polar surface area  1046.12

Aromaticity  0.04

Average rotatable bonds  3.48

Number of hydrogen bond donors  35

Number of hydrogen bond acceptors  34

X logP energy  -6.72156

Hydropathy 



Literature Information


Title  Signal peptide prediction based on analysis of experimentally verified cleavage sites.

DOI  10.1110/ps.04682504,

Publication Year  2004

PubMed ID  15340161,

Patent ID  NA,



Faculty of Applied Sciences, Macao Polytechnic University, Macao, China.