SPKB

Signal Peptide Knowledge Base

General Information


SPKB ID  SPKB02399

Signal sequence   MTCSPLLLTLLIHCTGSWA

Length  19

Organism  Homo sapiens (Human)

UniProt ID  P01701,

Motif  1..19



Activity Information


Pathway  SRP-dependent

Natural/Artificial  Natural

Subcellular location  ER

Secretion efficiency  NA

Type  Sec/SPI



Structure Information


PDB ID  NA,

Predicted Structure ID  SPKB02399.cif

Structure  SPKB02399.cif
Very high (pLDDT > 90)
Confident (90 > pLDDT > 70)
Low (70 > pLDDT > 50)
Very low (pLDDT < 50)
Loading PAE…
Expected Position Error (Ångströms)


Physicochemical Information


Molecular weight  2060.51524

Aliphatic index  128.4210526

Isoelectric point  7.253156577

Charge (pH=7)   -0.035056042

Topological polar surface area  723.95

Aromaticity  0.052631579

Average rotatable bonds  3.263157895

Number of hydrogen bond donors  28

Number of hydrogen bond acceptors  29

X logP energy  -5.0117

Hydropathy 



Literature Information


Title  The amino-acid sequence of the variable region of a carbohydrate-containing amyloid fibril protein EPS (immunoglobulin light chain, type lambda).

DOI  10.1515/bchm3.1985.366.2.617,

Publication Year  1985

PubMed ID  3929803,

Patent ID  NA,



Faculty of Applied Sciences, Macao Polytechnic University, Macao, China.