SPKB

Signal Peptide Knowledge Base

General Information


SPKB ID  SPKB02396

Signal sequence   METPAQLLFLLLLWLPDTTG

Length  20

Organism  Homo sapiens (Human)

UniProt ID  P01619,

Motif  1..20



Activity Information


Pathway  SRP-dependent

Natural/Artificial  Natural

Subcellular location  ER

Secretion efficiency  NA

Type  Sec/SPI



Structure Information


PDB ID  7X7O,

Predicted Structure ID  SPKB02396.cif

Structure  SPKB02396.cif
Very high (pLDDT > 90)
Confident (90 > pLDDT > 70)
Low (70 > pLDDT > 50)
Very low (pLDDT < 50)
Loading PAE…
Expected Position Error (Ångströms)


Physicochemical Information


Molecular weight  2272.72764

Aliphatic index  141.5

Isoelectric point  3.550073557

Charge (pH=7)   -1.999794094

Topological polar surface area  792.81

Aromaticity  0.1

Average rotatable bonds  3.45

Number of hydrogen bond donors  26

Number of hydrogen bond acceptors  28

X logP energy  -1.9369

Hydropathy 



Literature Information


Title  The basic sequences of immunoglobulin kappa chains: Sequence studies of bence jones proteins Rad, Fr 4 and B6.

DOI  10.1016/0014-5793(69)80048-7,

Publication Year  1969

PubMed ID  11946339,

Patent ID  NA,



Faculty of Applied Sciences, Macao Polytechnic University, Macao, China.