SPKB

Signal Peptide Knowledge Base

General Information


SPKB ID  SPKB02393

Signal sequence   MDMRVPAQLLGLLLLWLRGARC

Length  22

Organism  Homo sapiens (Human)

UniProt ID  P01597,

Motif  1..22



Activity Information


Pathway  SRP-dependent

Natural/Artificial  Natural

Subcellular location  ER

Secretion efficiency  NA

Type  Sec/SPI



Structure Information


PDB ID  6WMW,

Predicted Structure ID  SPKB02393.cif

Structure  SPKB02393.cif
Very high (pLDDT > 90)
Confident (90 > pLDDT > 70)
Low (70 > pLDDT > 50)
Very low (pLDDT < 50)
Loading PAE…
Expected Position Error (Ångströms)


Physicochemical Information


Molecular weight  2526.16074

Aliphatic index  146.3636364

Isoelectric point  10.43741523

Charge (pH=7)   1.936446134

Topological polar surface area  947.51

Aromaticity  0.045454545

Average rotatable bonds  3.772727273

Number of hydrogen bond donors  35

Number of hydrogen bond acceptors  31

X logP energy  -3.94339

Hydropathy 



Literature Information


Title  The primary structure of a monoclonal kappa-type immunoglobulin L-chain of subgroup I (Bence-Jones Protein Hau): subdivision within subgroups

DOI  NA,

Publication Year  1970

PubMed ID  4097974,

Patent ID  NA,



Faculty of Applied Sciences, Macao Polytechnic University, Macao, China.