SPKB

Signal Peptide Knowledge Base

General Information


SPKB ID  SPKB02391

Signal sequence   MKNHLLFWGVLAVFIKAVHVKA

Length  22

Organism  Homo sapiens (Human)

UniProt ID  P01591,

Motif  1..22



Activity Information


Pathway  SRP-dependent

Natural/Artificial  Natural

Subcellular location  ER

Secretion efficiency  NA

Type  Sec/SPI



Structure Information


PDB ID  6LX3,

Predicted Structure ID  SPKB02391.cif

Structure  SPKB02391.cif
Very high (pLDDT > 90)
Confident (90 > pLDDT > 70)
Low (70 > pLDDT > 50)
Very low (pLDDT < 50)
Loading PAE…
Expected Position Error (Ångströms)


Physicochemical Information


Molecular weight  2522.13884

Aliphatic index  137.2727273

Isoelectric point  11.10310314

Charge (pH=7)   3.17891738

Topological polar surface area  868.72

Aromaticity  0.136363636

Average rotatable bonds  3.727272727

Number of hydrogen bond donors  30

Number of hydrogen bond acceptors  30

X logP energy  -0.7649

Hydropathy 



Literature Information


Title  Human Basal Tear Peptidome Characterization by CID, HCD, and ETD Followed by in Silico and in Vitro Analyses for Antimicrobial Peptide Identification.

DOI  10.1021/acs.jproteome.5b00179,

Publication Year  2015

PubMed ID  25946035,

Patent ID  NA,



Faculty of Applied Sciences, Macao Polytechnic University, Macao, China.