SPKB

Signal Peptide Knowledge Base

General Information


SPKB ID  SPKB02390

Signal sequence   MGVHECPAWLWLLLSLLSLPLGLPVLG

Length  27

Organism  Homo sapiens (Human)

UniProt ID  P01588,

Motif  1..27



Activity Information


Pathway  SRP-dependent

Natural/Artificial  Natural

Subcellular location  ER

Secretion efficiency  NA

Type  Sec/SPI



Structure Information


PDB ID  NA,

Predicted Structure ID  SPKB02390.cif

Structure  SPKB02390.cif
Very high (pLDDT > 90)
Confident (90 > pLDDT > 70)
Low (70 > pLDDT > 50)
Very low (pLDDT < 50)
Loading PAE…
Expected Position Error (Ångströms)


Physicochemical Information


Molecular weight  2928.62984

Aliphatic index  169.6296296

Isoelectric point  5.36107726

Charge (pH=7)   -0.971306203

Topological polar surface area  931.57

Aromaticity  0.074074074

Average rotatable bonds  3.222222222

Number of hydrogen bond donors  32

Number of hydrogen bond acceptors  34

X logP energy  0.1549

Hydropathy 



Literature Information


Title  Structural characterization of human erythropoietin.

DOI  NA,

Publication Year  1986

PubMed ID  3949763,

Patent ID  NA,



Faculty of Applied Sciences, Macao Polytechnic University, Macao, China.