SPKB

Signal Peptide Knowledge Base

General Information


SPKB ID  SPKB02375

Signal sequence   MQRLCVYVLIFALALAAFSEA

Length  21

Organism  Homo sapiens (Human)

UniProt ID  P01350,

Motif  1..21



Activity Information


Pathway  SRP-dependent

Natural/Artificial  Natural

Subcellular location  ER

Secretion efficiency  NA

Type  Sec/SPI



Structure Information


PDB ID  NA,

Predicted Structure ID  SPKB02375.cif

Structure  SPKB02375.cif
Very high (pLDDT > 90)
Confident (90 > pLDDT > 70)
Low (70 > pLDDT > 50)
Very low (pLDDT < 50)
Loading PAE…
Expected Position Error (Ångströms)


Physicochemical Information


Molecular weight  2329.84394

Aliphatic index  144.2857143

Isoelectric point  6.229383416

Charge (pH=7)   -0.063069019

Topological polar surface area  828.07

Aromaticity  0.142857143

Average rotatable bonds  3.523809524

Number of hydrogen bond donors  30

Number of hydrogen bond acceptors  29

X logP energy  -2.76123

Hydropathy 



Literature Information


Title  Identification of gastrin component I as gastrin-71. The largest possible bioactive progastrin product.

DOI  10.1111/j.1432-1033.1994.tb19051.x,

Publication Year  1994

PubMed ID  8055952,

Patent ID  NA,



Faculty of Applied Sciences, Macao Polytechnic University, Macao, China.