SPKB

Signal Peptide Knowledge Base

General Information


SPKB ID  SPKB02370

Signal sequence   MALWMHLLTVLALLALWGPNTGQA

Length  24

Organism  Cavia porcellus (Guinea pig)

UniProt ID  P01329,

Motif  1..24



Activity Information


Pathway  SRP-dependent

Natural/Artificial  Natural

Subcellular location  ER

Secretion efficiency  NA

Type  Sec/SPI



Structure Information


PDB ID  NA,

Predicted Structure ID  SPKB02370.cif

Structure  SPKB02370.cif
Very high (pLDDT > 90)
Confident (90 > pLDDT > 70)
Low (70 > pLDDT > 50)
Very low (pLDDT < 50)
Loading PAE…
Expected Position Error (Ångströms)


Physicochemical Information


Molecular weight  2621.19674

Aliphatic index  142.5

Isoelectric point  7.550323994

Charge (pH=7)   0.08889339

Topological polar surface area  910.73

Aromaticity  0.083333333

Average rotatable bonds  3.333333333

Number of hydrogen bond donors  31

Number of hydrogen bond acceptors  32

X logP energy  -2.8015

Hydropathy 



Literature Information


Title  Species variation in the amino acid sequence of insulin.

DOI  10.1016/0002-9343(66)90145-8,

Publication Year  1966

PubMed ID  5949593,

Patent ID  NA,



Faculty of Applied Sciences, Macao Polytechnic University, Macao, China.