SPKB

Signal Peptide Knowledge Base

General Information


SPKB ID  SPKB02366

Signal sequence   MALWMRFLPLLALLVLWEPKPAQA

Length  24

Organism  Rattus norvegicus (Rat)

UniProt ID  P01322,

Motif  1..24



Activity Information


Pathway  SRP-dependent

Natural/Artificial  Natural

Subcellular location  ER

Secretion efficiency  NA

Type  Sec/SPI



Structure Information


PDB ID  NA,

Predicted Structure ID  SPKB02366.cif

Structure  SPKB02366.cif
Very high (pLDDT > 90)
Confident (90 > pLDDT > 70)
Low (70 > pLDDT > 50)
Very low (pLDDT < 50)
Loading PAE…
Expected Position Error (Ångströms)


Physicochemical Information


Molecular weight  2808.52494

Aliphatic index  142.5

Isoelectric point  9.695027686

Charge (pH=7)   0.999461077

Topological polar surface area  906.14

Aromaticity  0.125

Average rotatable bonds  3.541666667

Number of hydrogen bond donors  30

Number of hydrogen bond acceptors  31

X logP energy  1.84507

Hydropathy 



Literature Information


Title  Proinsulin and the biosynthesis of insulin.

DOI  10.1016/b978-0-12-571125-8.50008-9,

Publication Year  1969

PubMed ID  4311938,

Patent ID  NA,



Faculty of Applied Sciences, Macao Polytechnic University, Macao, China.