SPKB

Signal Peptide Knowledge Base

General Information


SPKB ID  SPKB02365

Signal sequence   MALWMRLLPLLALLALWAPAPTRA

Length  24

Organism  Canis lupus familiaris (Dog) (Canis familiaris)

UniProt ID  P01321,

Motif  1..24



Activity Information


Pathway  SRP-dependent

Natural/Artificial  Natural

Subcellular location  ER

Secretion efficiency  NA

Type  Sec/SPI



Structure Information


PDB ID  NA,

Predicted Structure ID  SPKB02365.cif

Structure  SPKB02365.cif
Very high (pLDDT > 90)
Confident (90 > pLDDT > 70)
Low (70 > pLDDT > 50)
Very low (pLDDT < 50)
Loading PAE…
Expected Position Error (Ångströms)


Physicochemical Information


Molecular weight  2689.40504

Aliphatic index  155

Isoelectric point  12.50010931

Charge (pH=7)   1.997977677

Topological polar surface area  881.86

Aromaticity  0.083333333

Average rotatable bonds  3.291666667

Number of hydrogen bond donors  31

Number of hydrogen bond acceptors  30

X logP energy  0.41704

Hydropathy 



Literature Information


Title  Species variation in the amino acid sequence of insulin.

DOI  10.1016/0002-9343(66)90145-8,

Publication Year  1966

PubMed ID  5949593,

Patent ID  NA,



Faculty of Applied Sciences, Macao Polytechnic University, Macao, China.