SPKB

Signal Peptide Knowledge Base

General Information


SPKB ID  SPKB02362

Signal sequence   MALWMRLLPLLALLALWGPDPAAA

Length  24

Organism  Homo sapiens (Human)

UniProt ID  P01308,

Motif  1..24



Activity Information


Pathway  SRP-dependent

Natural/Artificial  Natural

Subcellular location  ER

Secretion efficiency  NA

Type  Sec/SPI



Structure Information


PDB ID  6B3Q,

Predicted Structure ID  SPKB02362.cif

Structure  SPKB02362.cif
Very high (pLDDT > 90)
Confident (90 > pLDDT > 70)
Low (70 > pLDDT > 50)
Very low (pLDDT < 50)
Loading PAE…
Expected Position Error (Ångströms)


Physicochemical Information


Molecular weight  2604.25294

Aliphatic index  155

Isoelectric point  6.338718596

Charge (pH=7)   -0.001572528

Topological polar surface area  837.03

Aromaticity  0.083333333

Average rotatable bonds  3.166666667

Number of hydrogen bond donors  28

Number of hydrogen bond acceptors  29

X logP energy  0.87907

Hydropathy 



Literature Information


Title  Amino-acid sequence of human insulin.

DOI  10.1038/187483a0,

Publication Year  1960

PubMed ID  14426955,

Patent ID  NA,



Faculty of Applied Sciences, Macao Polytechnic University, Macao, China.