SPKB

Signal Peptide Knowledge Base

General Information


SPKB ID  SPKB02348

Signal sequence   MNIKGSPWKGSLLLLLVSNLLLCQSVAP

Length  28

Organism  Homo sapiens (Human)

UniProt ID  P01236,

Motif  1..28



Activity Information


Pathway  SRP-dependent

Natural/Artificial  Natural

Subcellular location  ER

Secretion efficiency  NA

Type  Sec/SPI



Structure Information


PDB ID  NA,

Predicted Structure ID  SPKB02348.cif

Structure  SPKB02348.cif
Very high (pLDDT > 90)
Confident (90 > pLDDT > 70)
Low (70 > pLDDT > 50)
Very low (pLDDT < 50)
Loading PAE…
Expected Position Error (Ångströms)


Physicochemical Information


Molecular weight  2995.67494

Aliphatic index  149.6428571

Isoelectric point  9.676237541

Charge (pH=7)   1.935419516

Topological polar surface area  1109.46

Aromaticity  0.035714286

Average rotatable bonds  3.5

Number of hydrogen bond donors  38

Number of hydrogen bond acceptors  40

X logP energy  -7.8397

Hydropathy 



Literature Information


Title  High sensitivity automated sequence determination of polypeptides.

DOI  NA,

Publication Year  1975

PubMed ID  1126929,

Patent ID  NA,



Faculty of Applied Sciences, Macao Polytechnic University, Macao, China.