SPKB

Signal Peptide Knowledge Base

General Information


SPKB ID  SPKB02345

Signal sequence   MEMLQGLLLLLLLSMGGAWA

Length  20

Organism  Homo sapiens (Human)

UniProt ID  P01229,

Motif  1..20



Activity Information


Pathway  SRP-dependent

Natural/Artificial  Natural

Subcellular location  ER

Secretion efficiency  NA

Type  Sec/SPI



Structure Information


PDB ID  NA,

Predicted Structure ID  SPKB02345.cif

Structure  SPKB02345.cif
Very high (pLDDT > 90)
Confident (90 > pLDDT > 70)
Low (70 > pLDDT > 50)
Very low (pLDDT < 50)
Loading PAE…
Expected Position Error (Ångströms)


Physicochemical Information


Molecular weight  2160.71914

Aliphatic index  166

Isoelectric point  3.849983241

Charge (pH=7)   -1.000240578

Topological polar surface area  732.63

Aromaticity  0.05

Average rotatable bonds  3.65

Number of hydrogen bond donors  25

Number of hydrogen bond acceptors  27

X logP energy  -0.9818

Hydropathy 



Literature Information


Title  Human pituitary lutropin. Isolation, properties, and the complete amino acid sequence of the beta-subunit.

DOI  NA,

Publication Year  1975

PubMed ID  1191677,

Patent ID  NA,



Faculty of Applied Sciences, Macao Polytechnic University, Macao, China.