SPKB

Signal Peptide Knowledge Base

General Information


SPKB ID  SPKB02322

Signal sequence   MKLITILFLCSRLLLSLT

Length  18

Organism  Homo sapiens (Human)

UniProt ID  P01042,

Motif  1..18



Activity Information


Pathway  SRP-dependent

Natural/Artificial  Natural

Subcellular location  ER

Secretion efficiency  NA

Type  Sec/SPI



Structure Information


PDB ID  NA,

Predicted Structure ID  SPKB02322.cif

Structure  SPKB02322.cif
Very high (pLDDT > 90)
Confident (90 > pLDDT > 70)
Low (70 > pLDDT > 50)
Very low (pLDDT < 50)
Loading PAE…
Expected Position Error (Ångströms)


Physicochemical Information


Molecular weight  2078.68604

Aliphatic index  195

Isoelectric point  9.833242293

Charge (pH=7)   1.935711238

Topological polar surface area  726.86

Aromaticity  0.055555556

Average rotatable bonds  3.944444444

Number of hydrogen bond donors  28

Number of hydrogen bond acceptors  27

X logP energy  -1.88113

Hydropathy 



Literature Information


Title  Cloning and sequence analysis of cDNAs for human high molecular weight and low molecular weight prekininogens. Primary structures of two human prekininogens.

DOI  NA,

Publication Year  1985

PubMed ID  2989293,

Patent ID  NA,



Faculty of Applied Sciences, Macao Polytechnic University, Macao, China.