SPKB

Signal Peptide Knowledge Base

General Information


SPKB ID  SPKB02315

Signal sequence   MGKNKLLHPSLVLLLLVLLPTDA

Length  23

Organism  Homo sapiens (Human)

UniProt ID  P01023,

Motif  1..23



Activity Information


Pathway  SRP-dependent

Natural/Artificial  Natural

Subcellular location  ER

Secretion efficiency  NA

Type  Sec/SPI



Structure Information


PDB ID  6TAV,

Predicted Structure ID  SPKB02315.cif

Structure  SPKB02315.cif
Very high (pLDDT > 90)
Confident (90 > pLDDT > 70)
Low (70 > pLDDT > 50)
Very low (pLDDT < 50)
Loading PAE…
Expected Position Error (Ångströms)


Physicochemical Information


Molecular weight  2499.13674

Aliphatic index  182.173913

Isoelectric point  9.539371756

Charge (pH=7)   1.088749807

Topological polar surface area  887.51

Aromaticity  0

Average rotatable bonds  3.565217391

Number of hydrogen bond donors  29

Number of hydrogen bond acceptors  32

X logP energy  -2.8454

Hydropathy 



Literature Information


Title  Primary structure of human alpha 2-macroglobulin. V. The complete structure.

DOI  NA,

Publication Year  1984

PubMed ID  6203908,

Patent ID  NA,



Faculty of Applied Sciences, Macao Polytechnic University, Macao, China.