SPKB

Signal Peptide Knowledge Base

General Information


SPKB ID  SPKB02312

Signal sequence   MERMLPLLALGLLAAGFCPAVLC

Length  23

Organism  Homo sapiens (Human)

UniProt ID  P01011,

Motif  1..23



Activity Information


Pathway  SRP-dependent

Natural/Artificial  Natural

Subcellular location  ER

Secretion efficiency  NA

Type  Sec/SPI



Structure Information


PDB ID  9D7K,

Predicted Structure ID  SPKB02312.cif

Structure  SPKB02312.cif
Very high (pLDDT > 90)
Confident (90 > pLDDT > 70)
Low (70 > pLDDT > 50)
Very low (pLDDT < 50)
Loading PAE…
Expected Position Error (Ångströms)


Physicochemical Information


Molecular weight  2403.05844

Aliphatic index  148.6956522

Isoelectric point  6.135737489

Charge (pH=7)   -0.124193321

Topological polar surface area  785.14

Aromaticity  0.043478261

Average rotatable bonds  3.260869565

Number of hydrogen bond donors  28

Number of hydrogen bond acceptors  30

X logP energy  -1.86603

Hydropathy 



Literature Information


Title  The microheterogeneity of desialylated alpha 1-antichymotrypsin: the occurrence of two amino-terminal isoforms, one lacking a His-Pro dipeptide.

DOI  10.1016/0167-4838(89)90139-8,

Publication Year  1989

PubMed ID  2787670,

Patent ID  NA,



Faculty of Applied Sciences, Macao Polytechnic University, Macao, China.