SPKB

Signal Peptide Knowledge Base

General Information


SPKB ID  SPKB02303

Signal sequence   MDGWRRMPRWGLLLLLWGSCTFG

Length  23

Organism  Homo sapiens (Human)

UniProt ID  P00797,

Motif  1..23



Activity Information


Pathway  SRP-dependent

Natural/Artificial  Natural

Subcellular location  ER

Secretion efficiency  NA

Type  Sec/SPI



Structure Information


PDB ID  NA,

Predicted Structure ID  SPKB02303.cif

Structure  SPKB02303.cif
Very high (pLDDT > 90)
Confident (90 > pLDDT > 70)
Low (70 > pLDDT > 50)
Very low (pLDDT < 50)
Loading PAE…
Expected Position Error (Ångströms)


Physicochemical Information


Molecular weight  2752.31114

Aliphatic index  84.7826087

Isoelectric point  10.43741523

Charge (pH=7)   1.936446134

Topological polar surface area  1005.56

Aromaticity  0.173913043

Average rotatable bonds  3.695652174

Number of hydrogen bond donors  39

Number of hydrogen bond acceptors  33

X logP energy  -4.18549

Hydropathy 



Literature Information


Title  Isolation and characterization of recombinant human prorenin in Chinese hamster ovary cells.

DOI  10.1093/oxfordjournals.jbchem.a123347,

Publication Year  1991

PubMed ID  2016271,

Patent ID  NA,



Faculty of Applied Sciences, Macao Polytechnic University, Macao, China.