SPKB

Signal Peptide Knowledge Base

General Information


SPKB ID  SPKB02294

Signal sequence   MRALLARLLLCVLVVSDSKG

Length  20

Organism  Homo sapiens (Human)

UniProt ID  P00749,

Motif  1..20



Activity Information


Pathway  SRP-dependent

Natural/Artificial  Natural

Subcellular location  ER

Secretion efficiency  NA

Type  Sec/SPI



Structure Information


PDB ID  NA,

Predicted Structure ID  SPKB02294.cif

Structure  SPKB02294.cif
Very high (pLDDT > 90)
Confident (90 > pLDDT > 70)
Low (70 > pLDDT > 50)
Very low (pLDDT < 50)
Loading PAE…
Expected Position Error (Ångströms)


Physicochemical Information


Molecular weight  2157.70444

Aliphatic index  170.5

Isoelectric point  9.828249571

Charge (pH=7)   1.936154411

Topological polar surface area  843.8

Aromaticity  0

Average rotatable bonds  3.7

Number of hydrogen bond donors  32

Number of hydrogen bond acceptors  29

X logP energy  -5.67696

Hydropathy 



Literature Information


Title  Characterization of a posttranslational fucosylation in the growth factor domain of urinary plasminogen activator.

DOI  10.1073/pnas.88.9.3992,

Publication Year  1991

PubMed ID  2023947,

Patent ID  NA,



Faculty of Applied Sciences, Macao Polytechnic University, Macao, China.