SPKB

Signal Peptide Knowledge Base

General Information


SPKB ID  SPKB02291

Signal sequence   MSDLGAVISLLLWGRQLF

Length  18

Organism  Homo sapiens (Human)

UniProt ID  P00739,

Motif  1..18



Activity Information


Pathway  SRP-dependent

Natural/Artificial  Natural

Subcellular location  ER

Secretion efficiency  NA

Type  Sec/SPI



Structure Information


PDB ID  NA,

Predicted Structure ID  SPKB02291.cif

Structure  SPKB02291.cif
Very high (pLDDT > 90)
Confident (90 > pLDDT > 70)
Low (70 > pLDDT > 50)
Very low (pLDDT < 50)
Loading PAE…
Expected Position Error (Ångströms)


Physicochemical Information


Molecular weight  2019.43244

Aliphatic index  151.6666667

Isoelectric point  6.338718596

Charge (pH=7)   -0.001572528

Topological polar surface area  756.56

Aromaticity  0.111111111

Average rotatable bonds  3.666666667

Number of hydrogen bond donors  27

Number of hydrogen bond acceptors  25

X logP energy  -3.43693

Hydropathy 



Literature Information


Title  A retained secretory signal peptide mediates high density lipoprotein (HDL) assembly and function of haptoglobin-related protein.

DOI  10.1074/jbc.M114.567578,

Publication Year  2014

PubMed ID  25037218,

Patent ID  NA,



Faculty of Applied Sciences, Macao Polytechnic University, Macao, China.