SPKB

Signal Peptide Knowledge Base

General Information


SPKB ID  SPKB02257

Signal sequence   MRPSGTAGAALLALLAALCPASRA

Length  24

Organism  Homo sapiens (Human)

UniProt ID  P00533,

Motif  1..24



Activity Information


Pathway  SRP-dependent

Natural/Artificial  Natural

Subcellular location  ER

Secretion efficiency  NA

Type  Sec/SPI



Structure Information


PDB ID  3QWQ,

Predicted Structure ID  SPKB02257.cif

Structure  SPKB02257.cif
Very high (pLDDT > 90)
Confident (90 > pLDDT > 70)
Low (70 > pLDDT > 50)
Very low (pLDDT < 50)
Loading PAE…
Expected Position Error (Ångströms)


Physicochemical Information


Molecular weight  2282.74774

Aliphatic index  114.5833333

Isoelectric point  10.52640717

Charge (pH=7)   1.936002961

Topological polar surface area  899.53

Aromaticity  0

Average rotatable bonds  2.916666667

Number of hydrogen bond donors  33

Number of hydrogen bond acceptors  32

X logP energy  -10.21156

Hydropathy 



Literature Information


Title  Signal peptide prediction based on analysis of experimentally verified cleavage sites.

DOI  10.1110/ps.04682504,

Publication Year  2004

PubMed ID  15340161,

Patent ID  NA,



Faculty of Applied Sciences, Macao Polytechnic University, Macao, China.