SPKB

Signal Peptide Knowledge Base

General Information


SPKB ID  SPKB02256

Signal sequence   MKILILGIFLFLCSTPAWA

Length  19

Organism  Homo sapiens (Human)

UniProt ID  P00450,

Motif  1..19



Activity Information


Pathway  SRP-dependent

Natural/Artificial  Natural

Subcellular location  ER

Secretion efficiency  NA

Type  Sec/SPI



Structure Information


PDB ID  2J5W,

Predicted Structure ID  SPKB02256.cif

Structure  SPKB02256.cif
Very high (pLDDT > 90)
Confident (90 > pLDDT > 70)
Low (70 > pLDDT > 50)
Very low (pLDDT < 50)
Loading PAE…
Expected Position Error (Ångströms)


Physicochemical Information


Molecular weight  2137.71244

Aliphatic index  154.2105263

Isoelectric point  8.545189979

Charge (pH=7)   0.93571455

Topological polar surface area  660.6

Aromaticity  0.157894737

Average rotatable bonds  3.473684211

Number of hydrogen bond donors  24

Number of hydrogen bond acceptors  25

X logP energy  1.0192

Hydropathy 



Literature Information


Title  Single-chain structure of human ceruloplasmin: the complete amino acid sequence of the whole molecule.

DOI  10.1073/pnas.81.2.390,

Publication Year  1984

PubMed ID  6582496,

Patent ID  NA,



Faculty of Applied Sciences, Macao Polytechnic University, Macao, China.