SPKB

Signal Peptide Knowledge Base

General Information


SPKB ID  SPKB02250

Signal sequence   MKLTKGCAYKYIIFTVLILANILYDNKKRC

Length  30

Organism  Plasmodium falciparum (isolate 3D7)

UniProt ID  O96935,

Motif  1..30



Activity Information


Pathway  SRP-dependent

Natural/Artificial  Natural

Subcellular location  ER

Secretion efficiency  NA

Type  Sec/SPI



Structure Information


PDB ID  8SLO,

Predicted Structure ID  SPKB02250.cif

Structure  SPKB02250.cif
Very high (pLDDT > 90)
Confident (90 > pLDDT > 70)
Low (70 > pLDDT > 50)
Very low (pLDDT < 50)
Loading PAE…
Expected Position Error (Ångströms)


Physicochemical Information


Molecular weight  3538.37174

Aliphatic index  120.3333333

Isoelectric point  10.02539459

Charge (pH=7)   4.870451628

Topological polar surface area  1323.85

Aromaticity  0.133333333

Average rotatable bonds  4.033333333

Number of hydrogen bond donors  49

Number of hydrogen bond acceptors  48

X logP energy  -6.25083

Hydropathy 



Literature Information


Title  Plasmodium falciparum PfA-M1 aminopeptidase is trafficked via the parasitophorous vacuole and marginally delivered to the food vacuole.

DOI  10.1186/1475-2875-9-189,

Publication Year  2010

PubMed ID  20591164,

Patent ID  NA,



Faculty of Applied Sciences, Macao Polytechnic University, Macao, China.