SPKB

Signal Peptide Knowledge Base

General Information


SPKB ID  SPKB02249

Signal sequence   MTMRHNWTPDLSPLWVLLLCAHVVTLLVRA

Length  30

Organism  Homo sapiens (Human)

UniProt ID  O95998,

Motif  1..30



Activity Information


Pathway  SRP-dependent

Natural/Artificial  Natural

Subcellular location  ER

Secretion efficiency  NA

Type  Sec/SPI



Structure Information


PDB ID  NA,

Predicted Structure ID  SPKB02249.cif

Structure  SPKB02249.cif
Very high (pLDDT > 90)
Confident (90 > pLDDT > 70)
Low (70 > pLDDT > 50)
Very low (pLDDT < 50)
Loading PAE…
Expected Position Error (Ångströms)


Physicochemical Information


Molecular weight  3487.24594

Aliphatic index  136.3333333

Isoelectric point  8.564715601

Charge (pH=7)   1.118267627

Topological polar surface area  1263.69

Aromaticity  0.066666667

Average rotatable bonds  3.533333333

Number of hydrogen bond donors  46

Number of hydrogen bond acceptors  44

X logP energy  -5.71666

Hydropathy 



Literature Information


Title  Interleukin-18 binding protein: a novel modulator of the Th1 cytokine response.

DOI  10.1016/s1074-7613(00)80013-8,

Publication Year  1999

PubMed ID  10023777,

Patent ID  NA,



Faculty of Applied Sciences, Macao Polytechnic University, Macao, China.