SPKB

Signal Peptide Knowledge Base

General Information


SPKB ID  SPKB02248

Signal sequence   MEKIPVSAFLLLVALSYTLA

Length  20

Organism  Homo sapiens (Human)

UniProt ID  O95994,

Motif  1..20



Activity Information


Pathway  SRP-dependent

Natural/Artificial  Natural

Subcellular location  ER

Secretion efficiency  NA

Type  Sec/SPI



Structure Information


PDB ID  NA,

Predicted Structure ID  SPKB02248.cif

Structure  SPKB02248.cif
Very high (pLDDT > 90)
Confident (90 > pLDDT > 70)
Low (70 > pLDDT > 50)
Very low (pLDDT < 50)
Loading PAE…
Expected Position Error (Ångströms)


Physicochemical Information


Molecular weight  2179.68624

Aliphatic index  161

Isoelectric point  6.402001171

Charge (pH=7)   -0.001386026

Topological polar surface area  751.67

Aromaticity  0.1

Average rotatable bonds  3.45

Number of hydrogen bond donors  26

Number of hydrogen bond acceptors  28

X logP energy  -1.9327

Hydropathy 



Literature Information


Title  Signal peptide prediction based on analysis of experimentally verified cleavage sites.

DOI  10.1110/ps.04682504,

Publication Year  2004

PubMed ID  15340161,

Patent ID  NA,



Faculty of Applied Sciences, Macao Polytechnic University, Macao, China.