SPKB

Signal Peptide Knowledge Base

General Information


SPKB ID  SPKB02247

Signal sequence   MRLSVCLLLLTLALCCYRANA

Length  21

Organism  Homo sapiens (Human)

UniProt ID  O95968,

Motif  1..21



Activity Information


Pathway  SRP-dependent

Natural/Artificial  Natural

Subcellular location  ER

Secretion efficiency  NA

Type  Sec/SPI



Structure Information


PDB ID  NA,

Predicted Structure ID  SPKB02247.cif

Structure  SPKB02247.cif
Very high (pLDDT > 90)
Confident (90 > pLDDT > 70)
Low (70 > pLDDT > 50)
Very low (pLDDT < 50)
Loading PAE…
Expected Position Error (Ångströms)


Physicochemical Information


Molecular weight  2340.94714

Aliphatic index  158.0952381

Isoelectric point  8.513867957

Charge (pH=7)   1.811203115

Topological polar surface area  872.9

Aromaticity  0.047619048

Average rotatable bonds  3.619047619

Number of hydrogen bond donors  35

Number of hydrogen bond acceptors  32

X logP energy  -5.60146

Hydropathy 



Literature Information


Title  Human Basal Tear Peptidome Characterization by CID, HCD, and ETD Followed by in Silico and in Vitro Analyses for Antimicrobial Peptide Identification.

DOI  10.1021/acs.jproteome.5b00179,

Publication Year  2015

PubMed ID  25946035,

Patent ID  NA,



Faculty of Applied Sciences, Macao Polytechnic University, Macao, China.