SPKB

Signal Peptide Knowledge Base

General Information


SPKB ID  SPKB02238

Signal sequence   MRALEGPGLSLLCLVLALPALLPVPAVRG

Length  29

Organism  Homo sapiens (Human)

UniProt ID  O95407,

Motif  1..29



Activity Information


Pathway  SRP-dependent

Natural/Artificial  Natural

Subcellular location  ER

Secretion efficiency  NA

Type  Sec/SPI



Structure Information


PDB ID  NA,

Predicted Structure ID  SPKB02238.cif

Structure  SPKB02238.cif
Very high (pLDDT > 90)
Confident (90 > pLDDT > 70)
Low (70 > pLDDT > 50)
Very low (pLDDT < 50)
Loading PAE…
Expected Position Error (Ångströms)


Physicochemical Information


Molecular weight  2940.68544

Aliphatic index  164.8275862

Isoelectric point  8.549845238

Charge (pH=7)   0.937778084

Topological polar surface area  1024.29

Aromaticity  0

Average rotatable bonds  3.103448276

Number of hydrogen bond donors  35

Number of hydrogen bond acceptors  36

X logP energy  -4.57926

Hydropathy 



Literature Information


Title  A newly identified member of tumor necrosis factor receptor superfamily (TR6) suppresses LIGHT-mediated apoptosis.

DOI  10.1074/jbc.274.20.13733,

Publication Year  1999

PubMed ID  10318773,

Patent ID  NA,



Faculty of Applied Sciences, Macao Polytechnic University, Macao, China.