SPKB

Signal Peptide Knowledge Base

General Information


SPKB ID  SPKB02226

Signal sequence   MRGTPKTHLLAFSLLCLLSKVRT

Length  23

Organism  Homo sapiens (Human)

UniProt ID  O76076,

Motif  1..23



Activity Information


Pathway  SRP-dependent

Natural/Artificial  Natural

Subcellular location  ER

Secretion efficiency  NA

Type  Sec/SPI



Structure Information


PDB ID  NA,

Predicted Structure ID  SPKB02226.cif

Structure  SPKB02226.cif
Very high (pLDDT > 90)
Confident (90 > pLDDT > 70)
Low (70 > pLDDT > 50)
Very low (pLDDT < 50)
Loading PAE…
Expected Position Error (Ångströms)


Physicochemical Information


Molecular weight  2586.19564

Aliphatic index  118.6956522

Isoelectric point  11.65160089

Charge (pH=7)   4.026321984

Topological polar surface area  1000.4

Aromaticity  0.043478261

Average rotatable bonds  3.739130435

Number of hydrogen bond donors  38

Number of hydrogen bond acceptors  36

X logP energy  -8.04306

Hydropathy 



Literature Information


Title  Signal peptide prediction based on analysis of experimentally verified cleavage sites.

DOI  10.1110/ps.04682504,

Publication Year  2004

PubMed ID  15340161,

Patent ID  NA,



Faculty of Applied Sciences, Macao Polytechnic University, Macao, China.