SPKB

Signal Peptide Knowledge Base

General Information


SPKB ID  SPKB02225

Signal sequence   MDLLWILPSLWLLLLGGPACLKT

Length  23

Organism  Homo sapiens (Human)

UniProt ID  O75636,

Motif  1..23



Activity Information


Pathway  SRP-dependent

Natural/Artificial  Natural

Subcellular location  ER

Secretion efficiency  NA

Type  Sec/SPI



Structure Information


PDB ID  NA,

Predicted Structure ID  SPKB02225.cif

Structure  SPKB02225.cif
Very high (pLDDT > 90)
Confident (90 > pLDDT > 70)
Low (70 > pLDDT > 50)
Very low (pLDDT < 50)
Loading PAE…
Expected Position Error (Ångströms)


Physicochemical Information


Molecular weight  2567.22904

Aliphatic index  173.9130435

Isoelectric point  6.160569088

Charge (pH=7)   -0.063838966

Topological polar surface area  821.3

Aromaticity  0.086956522

Average rotatable bonds  3.434782609

Number of hydrogen bond donors  29

Number of hydrogen bond acceptors  30

X logP energy  0.9277

Hydropathy 



Literature Information


Title  Signal peptide prediction based on analysis of experimentally verified cleavage sites.

DOI  10.1110/ps.04682504,

Publication Year  2004

PubMed ID  15340161,

Patent ID  NA,



Faculty of Applied Sciences, Macao Polytechnic University, Macao, China.